cosmedix Refine Rx
cosmedix Cosmedix Refine Rx lists 25 ingredients on its label, 23 decoded. See what each one does, its irritancy and comedogenic tendency, and its status in national inventories.
Ingredients overview
Label order. Colour is our internal rating: green routine, yellow restricted or worth a look, red prohibited or high-risk, grey not yet decoded.
Ingredients are listed in label order; the order reflects the label only, not exact concentrations.
- Aqua
- Hamamelis Virginiana Water
- Retinyl Acetate
- Glycerin
- Sodium Lactate
- Alcohol
- Sodium Pca
- Retinol
- Polysorbate 20
- Galactoarabinan
- Hydroxyproline
- Squalane
- Cassia Angustifolia Seed Polysaccharide
- Sorbitol
- Helianthus Annuus Seed Oil
- Dimethicone
- Proline
- Sodium Hyaluronate
- Lavandula Angustifolia Oil
- Santalum Album Oil
- Glucuronolactone
- Potassium Sorbate
- Carbomer
- Sodium Hydroxymethylglycinate
- Citric Acid
Highlights
Free of parabensFree of sulfatesFree of mineral oilContains alcoholContains PEGContains animal-derivedContains essential oilsContains siliconesContains EU-26 allergensContains fragranceContains formaldehyde releasers
Formulation view Witch hazel base with dual retinoid formulations, aided by alcohol for solubility. Galactomannan and hydrolyzed collagen support barrier repair; butylene glycol and glycerin hydrate. Suitable for resilient skin needing wrinkle control. Factory view: Alcohol volatility ensures light texture but may irritate; moisturizer dosage must be balanced.
Key ingredients
- SOLVENT
- Aqua
- ASTRINGENT
- Hamamelis Virginiana Water
- SKIN CONDITIONING - MISCELLANEOUS · 限制 III
- Retinyl AcetateRetinol
- DENATURANT
- Glycerin
- BUFFERING
- Sodium Lactate
- ANTIFOAMING
- Alcohol
- ANTISTATIC
- Sodium Pca
Other ingredients
Polysorbate 20GalactoarabinanHydroxyprolineSqualaneCassia Angustifolia Seed PolysaccharideSorbitolHelianthus Annuus Seed OilDimethiconeProlineSodium HyaluronateLavandula Angustifolia OilSantalum Album OilGlucuronolactonePotassium SorbateCarbomerSodium HydroxymethylglycinateCitric Acid
Skim through
| Ingredient | What it does | Irr. · Com. | Rating |
|---|---|---|---|
| Aqua | SOLVENT | 0 · 0 | Green |
| Hamamelis Virginiana Water | ASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING, SOOTHING | — | Green |
| Retinyl Acetate | SKIN CONDITIONING - MISCELLANEOUS · 限制 III/376 | 2 · – | Green |
| Glycerin | DENATURANT, HAIR CONDITIONING, HUMECTANT, ORAL CARE, SKIN PROTECTING, SOLVENT, VISCOSITY CONTROLLING, PERFUMING, FRAGRANCE, SKIN CONDITIONING - HUMECTANT | 0 · 0 | Green |
| Sodium Lactate | BUFFERING, HUMECTANT, KERATOLYTIC | 0 · – | Green |
| Alcohol | ANTIFOAMING, ANTIMICROBIAL, ASTRINGENT, FRAGRANCE, SOLVENT, VISCOSITY CONTROLLING | 1 · 0 | Yellow |
| Sodium Pca | ANTISTATIC, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING | – · 0 | Green |
| Retinol | SKIN CONDITIONING - MISCELLANEOUS · 限制 III/376 | 3 · 0 | Yellow |
| Polysorbate 20 | SURFACTANT - EMULSIFYING, SURFACTANT - CLEANSING | 0 · 0 | Green |
| Galactoarabinan | FILM FORMING | 0 · 0 | Green |
| Hydroxyproline | ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING, SURFACTANT - CLEANSING | 0 · 0 | Green |
| Squalane | SKIN CONDITIONING - EMOLLIENT, HAIR CONDITIONING, REFATTING, SKIN CONDITIONING | 0 · 0 | Green |
| Cassia Angustifolia Seed Polysaccharide | Not decoded yet | — | — |
| Sorbitol | HUMECTANT, FRAGRANCE, SKIN CONDITIONING, PERFUMING | 0 · 0 | Green |
| Helianthus Annuus Seed Oil | SKIN CONDITIONING - EMOLLIENT, SOLVENT, SKIN CONDITIONING - MISCELLANEOUS, SKIN CONDITIONING - OCCLUSIVE | 0 · 0 | Green |
| Dimethicone | ANTIFOAMING, SKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING | 0 · 0 | Green |
| Proline | HAIR CONDITIONING, SKIN CONDITIONING | 0 · 0 | Green |
| Sodium Hyaluronate | HUMECTANT, SKIN CONDITIONING | 0 · 0 | Green |
| Lavandula Angustifolia Oil | FRAGRANCE, TONIC · 限制 III/360 | 0 · – | Green |
| Santalum Album Oil | FRAGRANCE · 限制 III/367 | — | Yellow |
| Glucuronolactone | Not decoded yet | — | — |
| Potassium Sorbate | FRAGRANCE, PRESERVATIVE · 限制 V/4 | 0 · – | Yellow |
| Carbomer | EMULSION STABILISING, GEL FORMING, VISCOSITY CONTROLLING | 0 · 0 | Green |
| Sodium Hydroxymethylglycinate | HAIR CONDITIONING, PRESERVATIVE · 限制 V/51 | 0 · 0 | Yellow |
| Citric Acid | BUFFERING, CHELATING, FRAGRANCE | 1 · 0 | Green |
Ingredients explained
- Aqua
- Solvent, main base; microbial control is critical
- Hamamelis Virginiana Water
- Hamamelis water; tannins/flavonoids for astringent and soothing; low conc, generally well-tolerated
- Retinyl Acetate
- Retinyl acetate, vitamin A ester; restricted use (III/376), photosensitive, high concentrations cause irritation, control dosage.
- Glycerin
- Workhorse humectant at 3–10%; tacky at high levels, pair with occlusives
- Sodium Lactate
- Sodium lactate for moisturizing and exfoliation; pH buffering agent
- Alcohol
- Ethanol for solubility/drying at 5-15%; high conc. is drying/irritating, avoid lip/eye, low residue, balance with humectants.
- Sodium Pca
- Sodium PCA, NMF component, 1-10% humectant; salty/tacky at high levels.
- Retinol
- Highly active and unstable, needs robust antioxidant encapsulation; 0.1-1.0%, pregnancy contraindicated
- Polysorbate 20
- Non-ionic emulsifier and cleansing surfactant; contains PEG, control microbial load.
- Galactoarabinan
- Gum arabic polysaccharide; film-forming humectant; highly soluble.
- Hydroxyproline
- Amino acid derivative for humectancy and skin conditioning; supports collagen metabolism, water-soluble, gentle
- Squalane
- Emollient from plants or synthetic; light texture
- Cassia Angustifolia Seed Polysaccharide
- Not decoded yet
- Sorbitol
- Polyol humectant with strong hygroscopy; tacky at high levels, pair with occlusives; also a solvent or adjuster.
- Helianthus Annuus Seed Oil
- Sunflower seed oil for emollient/occlusive; high linoleic acid, low comedogenicity.
- Dimethicone
- Silicone occlusive at 1–5%; provides smooth feel, non-penetrating, suitable for sensitive skin
- Proline
- Proline, amino-acid humectant; boosts stratum corneum hydration, stable at pH 4-5.
- Sodium Hyaluronate
- Potent humectant at 0.1–2%; different MW for penetration depth, high levels may draw moisture
- Lavandula Angustifolia Oil
- Fragrance essential oil, 0.1–1%; contains allergens, patch test required.
- Santalum Album Oil
- Essential oil fragrance, restricted under EU 26; monitor sensitization and phototoxicity
- Glucuronolactone
- Not decoded yet
- Potassium Sorbate
- Preservative effective below pH 6; combinable with sodium benzoate
- Carbomer
- Gelling thickener requiring neutralization; watch out for ion compatibility
- Sodium Hydroxymethylglycinate
- Sodium hydroxymethylglycinate, hair conditioning and preservative; restricted concentration
- Citric Acid
- Buffer and chelator at 0.1–2%; adjusts pH, may irritate sensitive skin at low pH
Source: full ingredient list published on the product label, collected 2026-09-18. Ratings are our internal reading, not a regulatory conclusion. · Product page
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