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Cetaphil advanced defence serum am

Cetaphil cetaphil advanced defence serum am lists 35 ingredients on its label, 35 decoded. See what each one does, its irritancy and comedogenic tendency, and its status in national inventories.

Ingredients overview

Label order. Colour is our internal rating: green routine, yellow restricted or worth a look, red prohibited or high-risk, grey not yet decoded.

Ingredients are listed in label order; the order reflects the label only, not exact concentrations.

  1. Water
  2. Dicaprylyl Carbonate
  3. Glycerin
  4. 1,2-Hexanediol
  5. Polyglyceryl-6 Distearate
  6. Distarch Phosphate
  7. 4-T-Butylcyclohexanol
  8. Acrylates/C10-30 Alkyl Acrylate Crosspolymer
  9. Anhydroxylitol
  10. Bisabolol
  11. Caprylyl/Capryl Glucoside
  12. Cetyl Alcohol
  13. Citric Acid
  14. Dunaliella Salina Extract
  15. Ethylhexylglycerin
  16. Globularia Alypum Leaf Extract
  17. Hydrolyzed Hyaluronic Acid
  18. Jojoba Esters
  19. Palmitoyl Tripeptide-5
  20. Panthenol
  21. Pantolactone
  22. Pentylene Glycol
  23. Phenoxyethanol
  24. Polyglyceryl-3 Beeswax
  25. Polyisobutene
  26. Potassium Sorbate
  27. Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
  28. Sodium Benzoate
  29. Sodium Hyaluronate
  30. Sodium Hydroxide
  31. Sodium PCA
  32. Sorbitan Oleate
  33. Tocopherol
  34. Xylitol
  35. Xylitylglucoside

Highlights

Free of alcoholFree of parabensFree of siliconesFree of sulfatesFree of mineral oilFree of essential oilsFree of formaldehyde releasersContains fragranceContains animal-derived

Formulation view Light serum with dicaprylyl carbonate for freshness, glycerin/hexanediol for hydration, niacinamide for brightening, bisabolol for soothing. Suitable for mixed/sensitive skin. Factory note: Low-viscosity systems require balancing solubility of actives; preservation must be compatible with acidic components.

Key ingredients

ANTIPLAQUE
Water
SKIN CONDITIONING - EMOLLIENT
Dicaprylyl Carbonate
DENATURANT
Glycerin
SKIN CONDITIONING
1,2-Hexanediol
SURFACTANT - EMULSIFYING
Polyglyceryl-6 Distearate
ABSORBENT
Distarch Phosphate
FRAGRANCE
4-T-Butylcyclohexanol
EMULSION STABILISING
Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Other ingredients

AnhydroxylitolBisabololCaprylyl/Capryl GlucosideCetyl AlcoholCitric AcidDunaliella Salina ExtractEthylhexylglycerinGlobularia Alypum Leaf ExtractHydrolyzed Hyaluronic AcidJojoba EstersPalmitoyl Tripeptide-5PanthenolPantolactonePentylene GlycolPhenoxyethanolPolyglyceryl-3 BeeswaxPolyisobutenePotassium SorbateSodium Acrylate/Sodium Acryloyldimethyl Taurate CopolymerSodium BenzoateSodium HyaluronateSodium HydroxideSodium PCASorbitan OleateTocopherolXylitolXylitylglucoside

Skim through

IngredientWhat it doesIrr. · Com.Rating
WaterANTIPLAQUE, SKIN CONDITIONING, SOLVENT0 · 0Green
Dicaprylyl CarbonateSKIN CONDITIONING - EMOLLIENT, SKIN CONDITIONING0 · 0Green
GlycerinDENATURANT, HAIR CONDITIONING, HUMECTANT, ORAL CARE, SKIN PROTECTING, SOLVENT, VISCOSITY CONTROLLING, PERFUMING, FRAGRANCE, SKIN CONDITIONING - HUMECTANT0 · 0Green
1,2-HexanediolSKIN CONDITIONING, SOLVENT0 · 0Green
Polyglyceryl-6 DistearateSURFACTANT - EMULSIFYING0 · 0Green
Distarch PhosphateABSORBENT, ANTICAKING, BINDING0 · 0Green
4-T-ButylcyclohexanolFRAGRANCE, PERFUMING0 · –Green
Acrylates/C10-30 Alkyl Acrylate CrosspolymerEMULSION STABILISING, FILM FORMING, VISCOSITY CONTROLLING0 · 0Green
AnhydroxylitolHUMECTANT, SKIN CONDITIONING0 · 0Green
BisabololFRAGRANCE, SKIN CONDITIONING, SOOTHING0 · –Green
Caprylyl/Capryl GlucosideCLEANSING, FOAMING, SURFACTANT - CLEANSING0 · –Green
Cetyl AlcoholSKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMULSIFYING, EMULSION STABILISING, SURFACTANT - FOAM BOOSTING, FRAGRANCE, OPACIFYING, SURFACTANT - CLEANSING, VISCOSITY CONTROLLING1 · 1Green
Citric AcidBUFFERING, CHELATING, FRAGRANCE1 · 0Green
Dunaliella Salina ExtractSKIN CONDITIONINGGreen
EthylhexylglycerinDEODORANT, SKIN CONDITIONING0 · 0Green
Globularia Alypum Leaf ExtractSKIN CONDITIONINGGreen
Hydrolyzed Hyaluronic AcidHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING0 · 0Green
Jojoba EstersSKIN CONDITIONING - EMOLLIENT, MOISTURISING, SKIN CONDITIONING, SOOTHING0 · 0Green
Palmitoyl Tripeptide-5SKIN CONDITIONING - MISCELLANEOUS0 · 0Green
PanthenolANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING0 · 0Green
PantolactoneHUMECTANT, SKIN CONDITIONING0 · 0Green
Pentylene GlycolSKIN CONDITIONING, SOLVENT0 · 0Green
PhenoxyethanolANTIMICROBIAL, PRESERVATIVE · 限制 V/291 · 0Yellow
Polyglyceryl-3 BeeswaxSURFACTANT - EMULSIFYING0 · –Green
PolyisobuteneBINDING, FILM FORMING, VISCOSITY CONTROLLING0 · 1Green
Potassium SorbateFRAGRANCE, PRESERVATIVE · 限制 V/40 · –Yellow
Sodium Acrylate/Sodium Acryloyldimethyl Taurate CopolymerANTICAKING, EMULSION STABILISING, FILM FORMING, OPACIFYING, VISCOSITY CONTROLLING0 · 0Green
Sodium BenzoateANTICORROSIVE, FRAGRANCE, PRESERVATIVE · 限制 V/10 · –Yellow
Sodium HyaluronateHUMECTANT, SKIN CONDITIONING0 · 0Green
Sodium HydroxideBUFFERING, DENATURANT · 限制 III/15a3 · –Green
Sodium PCAANTISTATIC, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING– · 0Green
Sorbitan OleateSURFACTANT - EMULSIFYING0 · 0Green
TocopherolANTIOXIDANT, FRAGRANCE, SKIN CONDITIONING - MISCELLANEOUS, SKIN CONDITIONING - OCCLUSIVE0 · 0Green
XylitolANTI-SEBORRHEIC, DEODORANT, HUMECTANT, FLAVOURING, SKIN CONDITIONING - HUMECTANT0 · 0Green
XylitylglucosideHUMECTANT, SKIN CONDITIONING0 · 0Green

Ingredients explained

Water
Primary solvent and base; requires preservative system to prevent microbial growth
Dicaprylyl Carbonate
Light emollient solvent at 5–15%; mineral oil-free, refreshing feel, low sensitization.
Glycerin
Workhorse humectant at 3–10%; tacky at high levels, pair with occlusives
1,2-Hexanediol
Polyol solvent and preservative booster at 1–5%; light feel, can replace some traditional preservatives
Polyglyceryl-6 Distearate
Non-ionic emulsifier; mild, PEG-free, good compatibility for cream systems.
Distarch Phosphate
Crosslinked starch phosphate; absorbent/anticaking, may feel dry at high levels
4-T-Butylcyclohexanol
Fixative and scent masker; not a primary skin conditioning agent.
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Crosspolymer for thickening/film; needs neutralization to pH 7-8 to hydrate, check ion strength.
Anhydroxylitol
Anhydrous xylitol, potent humectant; high hygroscopicity may cause stickiness at high levels.
Bisabolol
Soothing and anti-inflammatory agent, 0.01–0.1%; low irritation, good for sensitive skin.
Caprylyl/Capryl Glucoside
Caprylyl/capryl glucoside, mild sugar surfactant; low irritation, moderate cleansing
Cetyl Alcohol
Cetyl alcohol for emulsification/thickening; high concentration >10% may irritate.
Citric Acid
Buffer and chelator at 0.1–2%; adjusts pH, may irritate sensitive skin at low pH
Dunaliella Salina Extract
Microalgal extract used as a skin conditioning agent for soothing and barrier support; no public irritancy or comedogenic data.
Ethylhexylglycerin
Mild conditioner and preservative booster at 0.5–1%; reduces preservative load, smooth feel
Globularia Alypum Leaf Extract
Yellow globularia leaf extract for anti-inflammatory and antioxidant effects; monitor plant toxins.
Hydrolyzed Hyaluronic Acid
Low-MW humectant with superior penetration vs high-MW; 0.1-0.5% typical, hygroscopic, store dry to prevent clumping.
Jojoba Esters
Jojoba esters, light emollient ester, low comedogenic; sebum-like, excellent spreadability.
Palmitoyl Tripeptide-5
Peptide actives for skin conditioning; typically used at low levels.
Panthenol
Panthenol (vitamin B5) at 1–5%; moisturizing and reparative, supports barrier recovery
Pantolactone
Pantolactone, humectant; hydrolyzes to release panthenol, improves skin hydration, low level use, high safety
Pentylene Glycol
Polyol humectant at 1-3%; low irritancy, suitable for sensitive skin
Phenoxyethanol
Broad-spectrum preservative at ≤1%; may irritate sensitive eye areas, often paired with ethylhexylglycerin
Polyglyceryl-3 Beeswax
Beeswax-derived emulsifier, mild and biodegradable; offers emollience for sensitive formulations
Polyisobutene
Inert film former and occlusive; increases viscosity, slippery feel, used in lipsticks
Potassium Sorbate
Preservative effective below pH 6; combinable with sodium benzoate
Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Acrylate copolymer for film/thickening; water-soluble, compatible, monitor residual monomers.
Sodium Benzoate
Preservative booster, effective below pH 4.5; combinable with sorbates
Sodium Hyaluronate
Potent humectant at 0.1–2%; different MW for penetration depth, high levels may draw moisture
Sodium Hydroxide
Strong base neutralizer for pH adjustment; handle with extreme care
Sodium PCA
Sodium PCA, NMF component, 1-10% humectant; salty/tacky at high levels.
Sorbitan Oleate
Non-ionic emulsifier for oil-in-water systems; plant-derived, check oxidative stability
Tocopherol
Natural antioxidant (vitamin E) at 0.1–1%; prone to oxidation, store protected from light
Xylitol
Polyol humectant, sweet taste; water-soluble, high hygroscopy, excess draws moisture.
Xylitylglucoside
Polyol humectant with high water absorption and fresh feel; often co-used with propylene glycol for enhanced hydration.

Source: full ingredient list published on the product label, collected 2026-09-17. Ratings are our internal reading, not a regulatory conclusion. · Product page

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